Citation
All O-PDX models and associated data are available. While there is no obligation to collaborate when requesting these samples, we ask that you cite the following reference in publications resulting from use of CSTN resources:
Stewart, E,* Federico, S,* Chen, X,* et al, Orthotopic patient-derived xenografts of paediatric solid tumours. Nature. 2017 Sep 7;549(7670):96-100
Protocols
SOPs for processing and propagating O-PDX
ChIP Seq Protocols visualized in the epigenetic data browsers
PK Reports
Preclinical Pharmacokinetic (PK) data are available for a number of high-priority drugs being explored for activity against pediatric solid tumors. If interested in other drugs, please inquire using the Request form, and data will be provided if it’s available. Attached files and additional details may also be requested using the Request form.
Publications
- Stewart*, McEvoy*, Wang*, Chen* et al Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses Cancer Cell 2018.
Abstract | Full Text - Stewart, E, et al, The Childhood Solid Tumor Network: A new resource for the developmental biology and oncology research communities. Dev. Biol 2016.
Abstract | Full text - Stewart E et al Development and characterization of a human orthotopic neuroblastoma xenograft, Developmental Biology 2016
Abstract | Full Text - Pinto EM, et al, Genomic landscape of paediatric adrenocortical tumours. Nat Commun 2015.
Abstract | Full Text - Lu C, et al, The genomic landscape of childhood and adolescent melanoma. J Invest Dermatol 2015.
Abstract | Full Text - Stewart E, et al, Targeting the DNA Repair Pathway in Ewing Sarcoma. Cell Reports 2014.
Abstract | Full Text - Tirode F, et al, Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations. Cancer Discov 2014.
Abstract | Full Text - Chen X, et al, Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma. Cell Rep 2014.
Abstract | Full Text - Chen X, et al, Targeting oxidative stress in embryonal rhabdomyosarcoma. Cancer Cell 2013.
Abstract | Full Text - Cheung NK, et al, Association of age at diagnosis and genetic mutations in patients with neuroblastoma. JAMA 2012.
Abstract | Full Text - Zhang J, et al, A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature 2012.
Abstract | Full Text