About Us

All O-PDX models described in the portal are freely available to academic researchers by request. The protocols used to propagate and process the O-PDX models are also freely shared. By early 2021, more than 230 PIs all over the world have requested and received over 1,600 tumor vials to advance scientific discovery.

The integration of data from multi-omics and beyond on this portal provides a rich resource for both academic and industrial research communities to find the appropriate models to advance the knowledge and therapeutic solutions to catastrophic childhood solid tumors. Importantly, the raw genomics sequencing data is also available from St Jude Cloud, following a straightforward application and approval process for access.

CSTN freely shares resources with no commitment to collaborate. The mission of CSTN is to support basic and translational research advances in pediatric solid tumors.

CSTN was established to disseminate resources and data that have been developed at St. Jude Children’s Research Hospital, with the aim of stimulating basic research and speeding translation to the clinic. The effort was launched in 2013 by Howard Hughes Medical Institute investigator Michael Dyer, PhD, of St. Jude Developmental Neurobiology, and Alberto Pappo, MD, of St. Jude Oncology.