Childhood Solid Tumor Models for Research and Discovery

The CSTN Data Portal provides access to orthotopic patient-derived xenograft models of childhood solid tumors and data.

The CSTN Data Portal is an innovative cloud-based data portal developed to stimulate basic research and speeding translation to the clinic. The portal allows researchers to explore various biological features of our pediatric O-PDX models, which provide both in vivo and in vitro systems to study mechanisms of disease origin, tumor progression and preclinical testing.

All O-PDX models described in the portal are freely available to academic researchers by request. The protocols used to propagate and process the O-PDX models are also freely shared. By 2020, more than 200 PIs all over the world have requested and received over 1500 tumor vials to advance scientific discovery.

Disease Types

The vast diversity of the collected childhood solid tumors is represented in more than 150 O-PDX models, consisting of over 20 diagnoses, including neuroblastoma, rhabdomyosarcoma and rare tumors.

Search Disease Types
Sample-Level Data

The models have been characterized and compared with the original patient tumor using various methods and assays including histology, electron microscopy, genomic sequencing, clonal analysis, and more.

Review Data Types
Sample and Gene Search

Data on O-PDX models can be visualized and compared in this data portal. The interface allows both gene and sample level search and visualization. All O-PDX samples are also freely available on request.

Search Samples & Genes

The integration of data from multi-omics and beyond on this portal provides a rich resource for both academic and industrial research communities to find the appropriate models to advance the knowledge and therapeutic solutions to catastrophic childhood solid tumors. Importantly, the raw genomics sequencing data is also available from St Jude Cloud, following a straightforward application and approval process for access.

CSTN freely shares resources with no commitment to collaborate. The mission of CSTN is to support basic and translational research advances in pediatric solid tumors.

CSTN was established to disseminate resources and data that have been developed at St. Jude Children’s Research Hospital, with the aim of stimulating basic research and speeding translation to the clinic. The effort was launched in 2013 by Howard Hughes Medical Institute investigator Michael Dyer, PhD, of St. Jude Developmental Neurobiology, and Alberto Pappo, MD, of St. Jude Oncology.